USMLE (United States Medical Licensing Examination) Step 1 Practice Exam

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What is the most common nonmalignant cause of hypercalcemia?

  1. Primary hyperparathyroidism

  2. Primary B-cell lymphoma

  3. Neuroblastoma

  4. Addison disease

The correct answer is: Primary hyperparathyroidism

Hypercalcemia is a condition where there is too much calcium present in the blood. When looking at the options provided, we can see that primary hyperparathyroidism is the only nonmalignant (not caused by cancer) condition listed. Primary B-cell lymphoma and neuroblastoma are both types of cancer, while Addison disease is an endocrine disorder. Therefore, A is the most common nonmalignant cause of hypercalcemia.

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